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Abstract #4. Accepted at Sleep Conference, 2014
Title:Obstructive sleep apnea and autoimmune disorders”, accepted at at American Academy of Sleep Medicine Annual Meeting, June 2014, Minneapolis, MN, USA.
Introduction: 15% of adults exhibit OSA in general population, majority of which remain undiagnosed. OSA has been associated with chronic inflammation and heart disease; however, no direct pathway is explained. Autoimmune disorders due to OSA may be such possibilities and the purpose of this study is to investigate such paradigms in clinical setting.
This is retrospective analysis of 400 patients in private practice clinic at San Angelo, Texas. OSA being an outcome was diagnosed by sleep specialist. Socio-demographic, laboratory and clinical information were obtained from medical records. Logistic models were employed to determine association between risk factors and OSA.
Results: One third (31%) of patient population suffered from OSA. More than half (51%) were aged (age>65), 56% female and three-fourth were White. Among those with OSA, 86% were obese, 81% were asthmatic, 17% were hypertensive, 29% had a lung perfusion 1.200) while only 4% patients without OSA suffered from Lupus.
Univariate analysis exhibited associated of OSA with low DLC0, diabetes, hypertension, age65) have twice odds of developing OSA (p=0.003, p=0.014) compared to control group. Multivariate logistic regression after controlling for age, gender ethnicity depicted that one-unit increase in BMI result in 9 % increase in odds of OSA (P=0.000). B2IgA exhibit significant relationship with outcome (P=0.017). Patients with lupus were 4-times more likely to suffer OSA (P=0.007).
Understanding the role of OSA in onset of autoimmune disorder is vital and will further help us in unraveling the association of OSA with chronic diseases. We hope that this finding will spur further research in this direction and advance policies to improve early detection, prevention, and control of OSA in co-morbid patients.