The novel insights into associations of immunoglobulin with asthma in adult patients
Previous research has suggested positive relationship between IgE antibodies allergic asthma. The association of IgA deficiency and asthma is a well-known fact and but no one has hypothesized the protective role of IgG in asthma.
Methods: The present study was aimed at a comprehensive analysis of IgA, IgM and IgG levels and their protective or causative association with asthma in adult lung patients. All the adult patients examined at Ayass Lung Clinic & Sleep Center at San Angelo, Texas, who consented for the blood test were included in the study. Socio-demographic, laboratory and clinical information were obtained from medical records. Two hundred and ninety seven asthmatic patients (median age 64 years) were screened for the levels of immunoglobulin. We also studied Ninety seven non-asthmatic patients (median age 70 years) as controls.
Results: The prevalence of higher IgA>453, IgG>1560, and IgM>305 levels in our study population were, 17%, 17% and 15% but in asthmatic patients the levels were 62%, 64% and 68% respectively.
Multivariate logistic regression analysis, after controlling for age, gender and ethnicity were as follow; IgA (OR 0.50; 95% CI, 0.28-0.90; P<0.05), IgG (OR 0.53; 95% CI, 0.29-0.93; P<0.05). Higher levels of IgA and IgG immunoglobulin were less likely to develop asthma and IgM association was not statistically significant.
Conclusions: So higher levels of IgA and IgG are more likely to be protective in terms of development of asthma but additional prospective studies will help to further understand the underlying mechanism of negative association/protection.