Abstract #7

 

 

Prevalence and Correlates of Immunoglobulin IgG deficiency in Adult Outpatient Population

 

Rationale:
IgG subclasses are low in 2.5 percent of the general population. Few studies have explored the prevalence and risk factors for IgG deficiency in adult patient population. 

Methods:  Four hundred patients examined at Ayass Lung Clinic & Sleep Center in 2013 were included in the study to analyzed IgG levels and their association with other diseases and immunoglobulin deficiencies. Demographic, clinical; and laboratory information were obtained from medical records. Logistic regression models were employed to determine association between risk factors and the presence of IgG deficiency.

Results: Seventy three patients (18%) were IgG deficient (< 750mg/dl). Among those who were IgG deficient were 18% deficient in IgM and 22% in IgA. Three quarter were aged (>65 years), 62% females and 92% were white. Analysis showed that being White, being in age groups >65, suffering from OSA and other immunoglobulin deficiencies were associated with the IgG deficiency. 

White adult patients compared to non-White patients were eight times more likely to develop IgG deficiency (CI, 02.30-30.0) after controlling for the demographics. Similarly patients with IgA deficiency and IgM deficiency, were 18 times (CI, 6.40-55.4) and 3.4 times (CI, 1.40-8.40) more likely to develop IgG deficiency, respectively. Patients with obstructive sleep apnea were 63% (CI, 0.17-0.78) and older patients were 73% less likely to develop IgG deficiency (CI, 0.14-0.53), respectively.

Conclusions: 

The prevalence of IgG deficiency in adult outpatient population is Texas was 18%. IgG subclass deficiency is the major phenotype of primary Immunodeficiency and being White, and suffering from OSA were associated with IgG deficiency.